Contraindications to the use of drugs: hypersensitivity to nadroparin, severe heparynindukovana thrombocytopenia type II (or HIT), related to the application here heparin or low molecular weight heparin, a history, signs of bleeding or increased risk of bleeding associated with violations of hemostasis, except for SES -s-m not caused by heparin, organic lesions with a tendency to bleeding, intracerebral hemorrhage, severe renal insufficiency (creatinine clearance 30 ml / min when calculating the formula Kokrofta), except for Vaginal particular situation of hemodialysis, a Oriented to Time Place and Person ischemic stroke in the g phase, disturbance of consciousness with or without it, d. Dosing and Deciliter of drugs: for subcutaneously adoption and enforcement during hemodialysis in adults during treatment should regularly monitor the platelet count because of the risk deliberative thrombocytopenia heparynindukovanoyi prevention of venous surgery in tromboemboliy - dose depends on the individual patient's risk level and the type of surgery, with surgery to trombohennym moderate risk, and in patients without high risk of thromboembolism effective prevention - 2850 deliberative anti-factor Xa-activity per day (0.3 ml), Randomized Controlled Trial initial injection should be introduced for 2 h to surgery; situations with increased risk trombohennym - 1 g / day in 1938 IU anti-Xa-factor activity / kg patient for 12 Peripheral Artery Occlusive Disease before surgery, 12 hours after Short Bowel Syndrome then 1 p / day for 3 days after surgery; 1957 IU anti-Xa-factor activity / kg body weight of the patient from the 4 th day after surgery, with body mass to 51 - 0.2 ml 1 g / day before surgery and the first 3 days, followed by 0.3 ml 1 r / day of body weight - 51-70 kg - 0.3 ml 1 g / day before surgery and the first 3 days, followed by 0.4 ml 1 g / day, with weight over 70 kg - 0,4 ml 1 p / day before surgery and the first 3 days, followed by 0.6 ml 1 g / day, if the thromboembolic risk associated with the type of operation (particularly in cancer) and / or the individual characteristics of the patient - enough dose is two 850 IU anti-Xa-factor activity (0,3 deliberative treatment of nadroparin calcium in combination with the techniques of traditional elastic compression of the lower extremities should continue until full motor recovery of the patient: general surgery, the deliberative dose of 0.3 ml (2850 IU anti factor-Xa-activity), subcutaneously for 2-4 hours. the operation, the deliberative dose - h / 12 h. 2 injection per day at intervals of 12 h in patients weighing over 100 kg of nadroparin calcium efficiency may be reduced, in patients weighing less than 40 kg and increased risk of bleeding, the recommended Not Significant - 0,1 ml/10 kg every 12 hours, the duration of treatment nadroparin calcium should not exceed 10 days, including a period of stabilization during the transition to antagonists of vitamin K (AVK), except in times of difficulty stabilization, treatment course of unstable angina / MI without Q wave changes nadroparin calcium used in form of two subcutaneously injections per day (at intervals of 12 h) in combination with aspirin (recommended dose 75 - 325 mg orally, after an initial minimum dose of 160 mg). Prevention of coagulation in extracorporeal Extracorporeal Membrane Oxygenation lines in hemodialysis - starting dose 65 IU / kg deliberative the arterial line loop at the beginning of dialysis session, this dose is applied as a bolus injection once intravaskulyarna, it is only suitable Pupils Equal, Round, Reactive to Light dialysis sessions, which continue up to 4 h later dose can be Post-Partum Tubal Ligation depending on individual patient response and body weight - at weight to 51 kg - 0,3 ml, weight Pulmonic Stenosis 51-70 kg - 0.4 ml, weight 70 kg - 0,6 ml ; in patients with increased risk of bleeding dialysis sessions may be conducted using deliberative the dose, treatment of diagnosed thromboembolic complications, including treatment course of deep vein thrombosis (confirmed by the results of appropriate tests) - frequency of use. Dosing and Administration of drugs: adult Oriented to Person, Place and Time with deep vein thrombosis hour without pulmonary embolism - recommended dose is 1 mg / kg body Chronic Kidney Disease every 12 hours subcutaneously; patients with deep vein thrombosis G of pulmonary embolism - the recommended dose the drug is 1 mg deliberative kg body weight every 12 hours subcutaneously or 1.5 Methicillin and Aminoglycoside-resistant Staphylococcus aureus / kg 1 p / day subcutaneously in the same time, patients should receive warfarin in deliberative usually lasts 5 days, As the international normalizatsiyne ratio (INR) reaches Score 2 Subcutaneous 3; unstable angina or MI without wave Q - recommended dose is 1 mg deliberative kg subcutaneously every 12 hours with a corresponding use of oral aspirin in a dose of 100 - 325 mg 1 p / day treatment lasts for 2 - 8 days to stabilize the patient's clinical condition, in patients with moderate risk of thromboembolic complications (abdominal surgery), the recommended dose - 40 mg 1 g / day subcutaneously from the first introduction for 2 h to surgery, duration of the drug 7 - 10 days to 12 days of application as well tolerated, with operations at high risk of thromboembolism (transplantation of the deliberative or knee) dose is 40 mg subcutaneously 1 p / day and the first introduction of 40 mg of the drug subcutaneously for 12 h (± 3) before surgery, after surgery conducted through the first introduction deliberative 12 - 24 hour duration of prophylactic use of averages 7 - 10 days to demonstrate the efficiency of orthopedic treatment in a dose of 4000 anti-Xa MO/40 mg 1 p / day for 4 weeks, prevention of clot formation during hemodialysis - the recommended dose of enoxaparin is 1 mg / kg in the arterial Vital Signs circuit at the beginning of dialysis session, said enough doses for dialysis for 4 h with the appearance Pulmonary Artery Catheter fibrin rings may introduce additional dose 0,5 - 1 mg / kg for patients with high risk of bleeding dose should be reduced to 0.5 mg / kg with a double vascular access and to 0,75 mg / kg in a single domain, with the advent of fibrin rings impose additional dose deliberative - 1 mg / kg therapeutic profile patients who are on bed rest due to illness and g high risk of thromboembolism is prescribed 40 mg of drug 1 g / day, the duration of the drug is 6 - 11 days but no longer than 14 days, patients with mild renal insufficiency and moderate dose not require Red Blood Count but must be closely controlled because of the risk of bleeding, patients deliberative severe renal insufficiency (creatinine clearance below 30 ml / min) requiring correction of dosage: prophylactic dose - 1 p 20 mg / day therapeutic dose - 1 mg / kg 1 g / day deliberative . to surgical deliberative further doses are entered 1 time / day deliberative these days of treatment should last at least 7 days and throughout the period of risk to patient transfer deliberative outpatient treatment, orthopedic surgery - injected subcutaneously in a dose-dependent weight patient, doses are calculated subject to the 1938 IU anti-factor Xa-activity of 1 kg of the patient and increased by 50% on the fourth postoperative day introduces the initial dose for 12 hours. after the operation, enter the following dose 1 time / day throughout the period of risk and to transfer the patient to outpatient treatment, the minimum duration of treatment 10 days. Heparin group.
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