It is used here the brain and dental pain, high temperature in children, migraine attacks, disease, Mi-algiyah, arthritis, spondylitis, as well as algodismenoree. Bradykinin, in addition, stimulates sensory nerve endings (pain mediator). Among other oksikamov used lornoxicam and tenoksikam. Leukotrienes C4, D4, and E4 (tsisteinilovye leukotrienes) extend krovenos-nye vessels, increasing their permeability, reduce blood pressure and increase the tone of the bronchi. Kidney. Indomethacin is sometimes used for cleft botallova duct (due to the vasodilator action bewildered prostaglandins). The drug was appointed interior, rectally (in suppositories), as well as intramuscularly and intravenously. Prostaglandins E2 and 12 extend the arterioles and increase the influence of histamine and bradykinin on the permeability postkapillyarnyh venules, as well as the effect of bradykinin on sensory nerve endings. Myometrium. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen bewildered filtering glomerulus. Ibuprom-phen, which bewildered inhibits both here a less dangerous. Especially pronounced ulcerogenic effect in inhibiting TSOG1. When algodismenoree NSAIDs relieve pain 1) Haemophilus Influenzae B analgesic properties, 2) due to the weakening of abbreviations myometrium (weakening of the uterotonic action of prostaglandin F2a). Acetylsalicylic acid bewildered is used as a pro-tivovospalitelnogo, analgesic and antipyretic. Celecoxib prescribed 1-2 times a day for rheumatoid arthritis and osteoarthritis. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. Since aspirin inhibits cyclooxygenase, lipoxygenase is activated by way of conversion of arachidonic acid - formation of leukotrienes, which, inter alia, improve the tone of the bronchi. In allergic conjunctivitis drug is used as eye drops. FAT dilates blood vessels, increases vascular Surgery by reducing the em-blood pressure, increases the aggregation platelets and bronchial tone. Due to bewildered fact that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid bewildered the formation of leukotrienes C4, D4, and E4, which increase the tone of the bronchi. Spermatogenesis. Mechanism anti-inflammatory action of these substances is associated with inhibition tsiklooksi-dehydrogenase. Naproxen (naprosin) appoint 2 times a day. Prostaglandin F2a stimulates spermatogenesis and increases the bewildered of sperm-ak bewildered . Included in the liniments applied to the friction with arthritis, myositis. Prostaglandin 12 (prostacyclin) inhibits platelet aggregation. Salicylates. Prostaglandins E2 and 12 have a gastroprotective action: reduce the secretion of HC1, increase mucus bewildered and the FNL, increase bewildered resistance of cells of gastric mucosa and here guts to damaging factors, improve mucosal blood flow. Indomethacin and acetylsalicylic acid bewildered TSOG1 more than TSOG2, and have a marked ulcerogenic action. Derivatives of propionic acid. Antipyretic effect of NSAIDs is associated with a decrease in production prostaglan-din E2 (infections interleykin1 secreted macrophages, stimulates the formation of prostaglandin E2, which activates the thermoregulatory centers in the hypothalamus). The analgesic effect of NSAIDs is also associated with a violation of Education pro-staglandinov E2 and 12, which increase the sensitivity pain receptors to bradykinin. Erosions and ulcers are accompanied by bleeding, which bewildered aggravated due to the antiplatelet properties of NSAIDs, can perforation of the stomach. In connection with the suppression of production of prostaglandins E2 and 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell of the stomach and duodenum. Diklofenaknatry derivatives of propionic acid Esophagogastroduodenoscopy Naproxen Piroxicam Meloxicam Oksikamy All of the above funds have basically three properties: anti-inflammatory, analgesic and antipyretic.
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